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KMID : 1240020130170040168
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International Neurourology Journal
2013 Volume.17 No. 4 p.168 ~ p.173
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Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population
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Seok Ho-Sik
Yoo Koo-Han
Kim Young-Ock
Chung Joo-Ho
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Abstract
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Purpose: Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH.
Methods: A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed.
Results: The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05).
Conclusion: We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
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KEYWORD
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Prostatic hyperplasia, Aldehyde dehydrogenase 2, Single nucleotide polymorphism
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